Rosa Pedrido Castiñeiras
Research is focused on the generation of metal complexes as both imaging agents and therapeutics. The team is interested in DNA recognition and metal-based anticancer drugs. Supramolecular chemistry is applied to construct large synthetic assemblies that can recognize DNA structures (major or minor groove, three-way junctions and so on). Furthermore, molecular design is also used to encode the precise micro-architecture, and to explore routes to encode additional information into the array, such as strand directionality, groove size and chirality. Hence, fluorescent anticancer metallodrugs are prepared with metal ions like Au(I), Ag(I) and Pt(II), and their uptake and localization are investigated by fluorescence microscopy. These compounds can be used as imaging tools to directly investigate relevant interactions between metallodrugs and different biomolecules. Combining supramolecular design with cisplatin-type design is also a topic of interest of this group, with the ultimate objective to achieve more efficient drugs.
Research group member:
María José Romero Castro
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7 March 2017: Conchita Gimeno is one of the awardees of the IUPAC 2017 Distinguished Women in Chemistry
14 october 2015: The Ministry of Economy and Competitiveness of Spain finances the network